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Showing 1 to 12 of 173 entries
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Perinatal 6-Hydroxydopamine Modeling of ADHD.

Current topics in behavioral neurosciences

Kostrzewa JP, Kostrzewa RA, Kostrzewa RM, Brus R, Nowak P.
PMID: 26475157
Curr Top Behav Neurosci. 2016;29:279-293. doi: 10.1007/7854_2015_397.

The neonatally 6-hydroxydopamine (n6-OHDA)-lesioned rat has been the standard for 40 years, as an animal model of attention-deficit hyperactivity disorder (ADHD). Rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta...

Lifelong Rodent Model of Tardive Dyskinesia-Persistence After Antipsychotic Drug Withdrawal.

Current topics in behavioral neurosciences

Kostrzewa RM, Brus R.
PMID: 26472552
Curr Top Behav Neurosci. 2016;29:353-362. doi: 10.1007/7854_2015_395.

Tardive dyskinesia (TD), first appearing in humans after introduction of the phenothiazine class of antipsychotics in the 1950s, is now recognized as an abnormality resulting predominately by long-term block of dopamine (DA) D

Impact of stress on prefrontal glutamatergic, monoaminergic and cannabinoid systems.

Current topics in behavioral neurosciences

Lapiz-Bluhm MD.
PMID: 25048388
Curr Top Behav Neurosci. 2014;18:45-66. doi: 10.1007/7854_2014_331.

Stress has been shown to have marked and divergent effects on learning and memory which involves specific brain regions, such as spatial and declarative memory involving the hippocampus, memory of emotional arousing experiences and fear involving the amygdala, and...

Psychophysiology of dissociated consciousness.

Current topics in behavioral neurosciences

Bob P.
PMID: 24850082
Curr Top Behav Neurosci. 2014;21:3-21. doi: 10.1007/7854_2014_320.

Recent study of consciousness provides an evidence that there is a limit of consciousness, which presents a barrier between conscious and unconscious processes. This barrier likely is specifically manifested as a disturbance of neural mechanisms of consciousness that through...

Preclinical assessment of pain: improving models in discovery research.

Current topics in behavioral neurosciences

King T, Porreca F.
PMID: 25012511
Curr Top Behav Neurosci. 2014;20:101-20. doi: 10.1007/7854_2014_330.

To date, animal models have not sufficiently "filtered" targets for new analgesics, increasing the failure rate and cost of drug development. Preclinical assessment of "pain" has historically relied on measures of evoked behavioral responses to sensory stimuli in animals....

Affective Biases in Humans and Animals.

Current topics in behavioral neurosciences

Robinson ES, Roiser JP.
PMID: 27311761
Curr Top Behav Neurosci. 2016 Jun 17; doi: 10.1007/7854_2015_5011. Epub 2016 Jun 17.

Depression is one of the most common but poorly understood psychiatric conditions. Although drug treatments and psychological therapies are effective in some patients, many do not achieve full remission and some patients receive no apparent benefit. Developing new improved...

Adult hippocampal neurogenesis in depression: behavioral implications and regulation by the stress system.

Current topics in behavioral neurosciences

Anacker C.
PMID: 24478038
Curr Top Behav Neurosci. 2014;18:25-43. doi: 10.1007/7854_2014_275.

Adult hippocampal neurogenesis, the birth of new neurons in the dentate gyrus of the adult brain, can be regulated by stress and antidepressant treatment, and has consistently been implicated in the behavioral neurobiology of stress-related disorders, especially depression and...

Mechanisms linking in utero stress to altered offspring behaviour.

Current topics in behavioral neurosciences

Mina TH, Reynolds RM.
PMID: 24577734
Curr Top Behav Neurosci. 2014;18:93-122. doi: 10.1007/7854_2014_291.

Development in utero is recognised as a determinant of health in later life, a concept known as early life 'programming'. Several studies in humans have now shown a link between in utero stressors of maternal stress, anxiety and depression...

Mechanisms and pharmacology of neuropathic pain in multiple sclerosis.

Current topics in behavioral neurosciences

Iannitti T, Kerr BJ, Taylor BK.
PMID: 24590824
Curr Top Behav Neurosci. 2014;20:75-97. doi: 10.1007/7854_2014_288.

The neuropathic pain of multiple sclerosis is quite prevalent and severely impacts quality of life. A few randomized, placebo-controlled, blinded clinical trials suggest that cannabis- and anticonvulsant-based treatments provide partial pain relief, but at the expense of adverse events....

Neurobehavioral Mechanisms of Traumatic Stress in Post-traumatic Stress Disorder.

Current topics in behavioral neurosciences

Lapiz-Bluhm MD, Peterson AL.
PMID: 24691656
Curr Top Behav Neurosci. 2014;18:161-90. doi: 10.1007/7854_2014_307.

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder that develops following trauma exposure. It is characterized by four symptom clusters: intrusion, avoidance, negative alteration in cognitions and mood, and alterations in arousal and reactivity. Several risk factors have...

The interaction between pain and social behavior in humans and rodents.

Current topics in behavioral neurosciences

Martin LJ, Tuttle AH, Mogil JS.
PMID: 24557935
Curr Top Behav Neurosci. 2014;20:233-50. doi: 10.1007/7854_2014_287.

Pain elicits behaviors in humans and nonhuman animals that serve as social cues. Pain behaviors serve a communicative function in humans, and this may be true as well in other animals. This review considers the current evidence for modulation...

Connectivity measurements for network imaging.

Current topics in behavioral neurosciences

Bowyer SM.
PMID: 25129140
Curr Top Behav Neurosci. 2014;21:315-30. doi: 10.1007/7854_2014_348.

Communication across the brain networks is dependent on neuronal oscillations. Detection of the synchronous activation of neurons can be used to determine the well-being of the connectivity in the human brain networks. Well-connected highly synchronous activity can be measured...

Showing 1 to 12 of 173 entries